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Seiff became the General Partner of Blockchange Ventures, a firm investing exclusively in early-stage blockchain companies, protocols, and applications.

Seiff entered venture capital by founding Beanstalk Ventures, a fund focused on investing in technologies to innovate the retail industry.

Ken Seiff founded the online retailer Bluefly.com, one of his early entrepreneurial ventures in the e-commerce space.

Seiff discussed his investment strategy and outlook on the multi-chain future on an episode of The Defiant podcast.