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McCauley co-founded Anchorage Digital with Diogo Mónica to provide a secure, regulated custody solution for institutional crypto investors.

Under McCauley's leadership, Anchorage Digital Bank, N.A. received a national trust charter from the U.S. Office of the Comptroller of the Currency (OCC).

McCauley testified before the U.S. Senate Banking Committee regarding the impacts of "debanking" on the digital asset industry.