Marc Andrusko is an American venture capitalist and a partner at Andreessen Horowitz (a16z), where he focuses on investments in B2B artificial intelligence (AI) applications and financial technology (fintech). ^{[1] [2]} Based in New York City, his career includes prior roles at the financial technology company Plaid and the investment bank Goldman Sachs. ^[3]​

Education

Andrusko attended Duke University, where he graduated magna cum laude. He pursued a multidisciplinary course of study that included Public Policy, Environmental Science, and Markets & Management. ^{[1] [2]}​

Career

Early Career

Andrusko began his career at Goldman Sachs, where he rose to the position of Vice President. During his time at the firm, he worked across several divisions, including corporate development, strategy, and interest rate products sales & trading. ^{[1] [2]}​

Following his tenure at Goldman Sachs, Andrusko joined Plaid, a technology company that builds data transfer networks for fintech. At Plaid, he led the personal financial management (PFM) vertical. In this capacity, he was responsible for building and launching partnerships aimed at improving consumer financial health. ^{[1] [2]}​

Andreessen Horowitz (a16z)

Andrusko is a B2B investment partner at Andreessen Horowitz. ^[3] His work involves identifying and supporting founders, with a stated focus on those building in "application layer software." ^[3]​

Role and Investment Focus

As a partner at a16z, Andrusko's investment interests are concentrated on B2B AI applications and fintech. His specific areas of focus include capital markets, payments infrastructure, and foundational financial infrastructure. He also has a particular interest in companies operating at the intersection of fintech and other major sectors, such as healthcare and vertical software. ^{[1] [2]}​

Andrusko has publicly commented on the firm's interest in how Generative AI will integrate into professional services, specifically noting the accounting and tax sectors in July 2023. ^[3] In November 2024, he remarked on how AI is redefining the sales cycle and the function of Customer Relationship Management (CRM) systems. ^[3]​

Investments

Andrusko has been involved in a number of investments for a16z. In December 2023, he announced the firm's participation in a $10 million investment in Spade, a provider of real-time merchant intelligence for the card payment ecosystem. ^[3] He has also co-authored investment announcements for several other companies, including:

• Camber: A platform designed to simplify healthcare reimbursement for providers.
• Crux: A company focused on financial market structure and asset classes.
• Eve: An AI-powered case workspace for plaintiff attorneys.
• Method: A platform for consumer debt management.
• Moment: An infrastructure company for embedding fixed-income investments into applications.
• Rillet: An AI-native Enterprise Resource Planning (ERP) system.

The investments listed above reflect Andrusko's focus on fintech, AI applications, and the convergence of finance with other industries like healthcare and legal services. ^[1]​

Thought Leadership and Commentary

Andrusko is a frequent author and podcast host for a16z's media platform, where he provides analysis on technology and market trends. ^[1] He also uses his social media presence to share insights and engage with the technology community. ^[3]​

Writings and Analysis

Through his writings, often co-authored with other a16z partners, Andrusko has explored several key themes:

• AI in the Enterprise: He has written about the transformative potential of generative AI on traditional business functions, including accounting, law, and sales. His analysis suggests that AI-native systems will automate complex workflows and redefine productivity in these sectors. ^[1]
• Fintech and Healthcare: Andrusko has co-authored articles on the convergence of fintech and healthcare, arguing for the need for a "financial operating system for healthcare" to address systemic inefficiencies in provider finances and patient billing. ^[1]
• Data Strategy: He has explored the strategic importance of proprietary data for building defensible AI companies, describing high-quality, exclusive datasets as "walled gardens" that can create a durable competitive advantage. ^[1]
• Fintech Infrastructure: Andrusko provides guidance for fintech founders on foundational topics, such as the trade-offs involved in building infrastructure and best practices for B2B pricing strategies. ^[1]

Media Appearances and Public Engagements

Andrusko hosts and appears on podcasts for a16z. He has hosted episodes discussing the use of AI in payments with executives from Mastercard and exploring AI and banking innovation with representatives from Citi. ^[1]​

He also participates in industry events. He was a featured moderator at the Money20/20 US conference for a session titled "How Startups Can Build Magical Customer Experiences." ^[2]​